There are two key factors that influence success in IVF treatment: a high-quality embryo and a healthy uterine lining (endometrium) where the embryo can implant. In some of our patients, even though high-quality embryos are obtained, pregnancy may not be achieved because the uterine lining does not reach sufficient thickness or the tissue quality is inadequate.
This is precisely where Endometrial PRP (Intrauterine PRP) therapy—one of the most important applications of regenerative medicine in recent years—comes into play.
What Is Endometrial PRP (Intrauterine PRP)?
PRP (Platelet-Rich Plasma) is a natural healing source derived from the patient’s own blood. How is the procedure performed?- A small amount of blood is drawn from the patient.
- This blood is processed through a special centrifugation procedure to separate it from red blood cells, yielding platelet cells that are extremely rich in growth factors.
- This concentrated plasma solution is then painlessly injected into the uterus (endometrial tissue) using a special catheter during in vitro fertilization (IVF) treatment.
What Are the Benefits of Intrauterine PRP Therapy?
The primary goal of endometrial PRP treatment is to stimulate cell division, blood flow, and tissue regeneration in the uterine lining. The main benefits are as follows:- Thickens the Uterine Lining: In cases where the uterine lining remains thinner than 7 mm despite medication, it helps achieve the ideal thickness by stimulating tissue growth.
- Increases the Chance of Embryo Implantation: Thanks to cell-regenerating and tissue-nourishing growth factors, it creates a more favorable and nourishing environment for the embryo to implant in the endometrium.
- Increases Intrauterine Blood Flow: By enhancing microcirculation and blood supply in the area, it ensures healthier nourishment of the uterine tissue.
- Supports the Repair of Damaged Tissues: It accelerates the healing process of thin or damaged endometrial linings resulting from previous dilation and curettage (D&C), intrauterine infections, or surgical interventions.
Who Is a Candidate for Endometrial PRP?
Endometrial PRP treatment is an important alternative for our patients undergoing in vitro fertilization (IVF) who experience the following conditions:- Those Experiencing Recurrent IVF Failure: Patients who have been unable to achieve pregnancy multiple times despite the transfer of high-quality embryos.
- Those with a Thin Uterine Lining (Refractory Endometrium): Women whose uterine lining does not reach the desired thickness despite treatment with estrogen and other medical therapies.
- Those with Asherman’s Syndrome or a History of Adhesions: To support the self-renewal of tissue following surgery to remove intrauterine adhesions (hysteroscopy).
How and When Is the Procedure Performed?
- Timing: It is typically performed a few days before embryo transfer or on days determined through ultrasound monitoring during the endometrial preparation (estrogen) process.
- Procedure: The procedure is performed in an outpatient setting on an examination table. It takes approximately 10–15 minutes.
- Pain Level: It is a painless procedure that does not require anesthesia and feels like a mild gynecological exam. The patient can return to her daily activities immediately after the procedure.
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